Chargement

Slzii.com Recherche

Recherche (Nouvelles)

歌礼选定同类首创口服小分子GIPR激动剂ASC48和口服小分子GLP-1R激动剂ASC30的固定剂量复方制剂进行临床开发
- ASC48 是一款有望成为同类首创( first-in-class )口服小分子的 GIPR 激动剂。 - 在人 GIPR ( hGIPR ) cAMP 激活实验中, ASC48 的 EC 50 为 1 pM ,展现出比替尔泊肽( EC 50 = 3 pM )更强的激动活性,且为 GIPR 的选择性激动剂,对 GLP-1R 和 GCGR 无激动活性。 - 在啮齿类动物和非人灵长类动物中, A SC48展现出了极佳的口服生物利用度、药物暴露量和较长的半衰期,支持在人体中每日一次口服给药。 - ASC30 与 ASC48 的固定剂量复方制剂( ASC30_48 FDC )同时靶向 GLP-1R 和 GIPR ,有望成为同类首创"每日一次、每次一片( one-pill, once-daily )"的口服肥胖症疗法。 - 在头对头非人灵长类动物研究中, ASC30_48 FDC 的减重效果较 ASC30 单药相对提升约 52% 。 - ASC30_48 FDC 是一款每日一次的口服小分子,其作用机制与目前市场领先的每周一次皮下注射 GLP/GIP 多肽药物替尔泊肽( 2025 年销售额超 300 亿美元)相同。 - 预计将于 2026 年第四季度向美国食品药品监督管理局( FDA )递交 ASC30_48 FDC 口服片的新药临床试验申请( IND )。 香港 , 2026年7月15日 /美通社/ -- 歌礼制药有限公司(香港联交所代码:1672,简称"歌礼")宣布,已选定有望成为同类首创(first-in-class)口服小分子的GIPR激动剂ASC48,和口服小分子GLP-1R激动剂ASC30的固定剂量复方制剂进行临床开发。ASC30与ASC48的固定剂量复方制剂(ASC30_48 FDC)同时靶向GLP-1R和GIPR,有望成为同类首创"每日一次、每次一片(one-pill, once-daily)"的口服肥胖症疗法。 ASC48是利用歌礼基于结构的AI辅助药物发现(AISBDD)技术自主研发的。在头对头人 GIPR(hGIPR) cAMP 激活实验中,ASC48的EC 50 为1 pM,展现出比替尔泊肽(EC 50 = 3 pM)更强的激动活性,且为GIPR的选择性激动剂,对GLP-1R和GCGR无激动活性。 在啮齿类动物和非人灵长类动物中,ASC48展现出了极佳的口服生物利用度、药物暴露量和较长的半衰期,支持在人体中每日一次口服给药。 在头对头非人灵长类动物研究中,ASC30_48 FDC的减重效果较ASC30单药相对提升约52%(表1)。 表1. 连续八天每日一次口服ASC30_48 FDC,其减重效果较ASC30及ASC48单药分别相对提升52%和518% 组别 给药 相较基线的 总体重变化 较ASC30单药或ASC48单药 的减重效果相对提升 ASC30(GLP-1R 激动 剂) 2 mg/kg 口服, 每日一次 -6.9 % NA ASC48(GIPR激动剂) 5 mg/kg 口服, 每日一次 -1.7 % NA ASC30_48 FDC(GLP- 1R/GIPR激动剂) 2 mg/kg ASC30 和 5 mg/kg ASC48 口服, 每日一次 -10.5 % 52% (对比ASC30单药) 518% (对比ASC48单药) 预计将于2026年第四季度向美国食品药品监督管理局(FDA)递交ASC30_48 FDC口服片的新药临床试验申请(IND)。 "我们期待开展这项临床试验,以评估ASC48与ASC30的固定剂量复方制剂,旨在开发出同类首创(first-in-class)的口服疗法,从而有望改善肥胖症患者的治疗效果。"歌礼创始人、董事会主席兼首席执行官吴劲梓博士表示,"我们认为,目前仍有未被满足的医疗需求,即需要一种口服药物,当其与GLP-1R疗法联合时,能够实现与每周注射一次的替尔泊肽相同的减重效果和耐受性。 " 关于歌礼制药有限公司 歌礼制药有限公司是一家全价值链整合型生物技术公司,聚焦有望成为治疗代谢疾病同类最佳(best-in-class)和同类首创(first-in-class)药物的开发和商业化。利用公司专有的基于结构的AI辅助药物发现(Artificial Intelligence-assisted Structure-Based Drug Discovery,AISBDD)、超长效药物开发平台(Ultra-Long-Acting Platform,ULAP)技术以及口服多肽递送增强技术(Peptide Oral Transport ENhancement Technology,POTENT),歌礼已自主研发多款小分子和多肽候选药物,包括其核心项目ASC30,一款在研小分子GLP-1R激动剂,既可每日一次口服也可每月一次至每季度一次皮下注射作为减重治疗疗法和减重维持疗法,用于长期体重管理;ASC36,一款胰淀素受体激动剂多肽,ASC35,一款每月一次皮下注射GLP-1R/GIPR双靶点激动剂多肽,ASC37,一款GLP-1R/GIPR/GCGR三靶点激动剂多肽,ASC39,一款类似eloralintide、对胰淀素具有选择性的强效口服小分子胰淀素受体激动剂,ASC30_39 FDC,ASC30(GLP-1RA)与ASC39(胰淀素受体激动剂)的固定剂量复方制剂(FDC),和ASC30_48 FDC,ASC30(GLP-1RA)与ASC48(GIP RA)的固定剂量复方制剂(FDC),用于长期体重管理。歌礼已在香港联交所上市(1672.HK)。 欲了解更多信息,敬请登录网站: www.ascletis.com 。 详情垂询: Peter Vozzo ICR Healthcare 443-231-0505 (美国) Peter.vozzo@icrhealthcare.com 歌礼制药有限公司PR和IR团队 +86-181-0650-9129 (中国) pr@ascletis.com ir@ascletis.com
2026-07-15 10:00:00

MAKER'S MARK LAUNCHES AIRPORT-EXCLUSIVE ARTIST SERIES
In time for summer travel, artist Alexandra Pacula brings iconic cityscapes to life in a limited-edition series exclusively for global travel retail LORETTO, Ky. , July 15, 2026 /PRNewswire/ -- Maker's Mark, the iconic handmade Kentucky bourbon, today announced a global travel retail exclusive series featuring custom, city-inspired labels designed by acclaimed artist Alexandra Pacula. Available for a limited time in select airports, the bespoke Maker's Mark bottles are inspired by destinations including New York, Los Angeles, Paris, London, Dubai, Delhi, Mumbai, Singapore, Seoul, Sydney and Melbourne, inviting travelers to discover and collect each release throughout their journeys. Maker's Mark Artist Series City Edition limited-edition bottles "At Maker's Mark, we've always believed that character comes from doing things differently, and this Artist Series – City Edition brings that idea to life by capturing the distinct spirit and creative energy of iconic cities around the world, " said Rob Samuels , eighth-generation whisky maker and managing director of Maker's Mark. "Today's travelers are looking for experiences that feel personal and memorable, and we're proud that each beautifully designed bottle is something they can enjoy long after their trip ends." Drawing on her signature style of painting inspired by long-exposure photography techniques, Pacula captures each city's movement, light and rhythm through layered, expressive compositions. Her process mirrors the craftsmanship behind every bottle of Maker's Mark, with hand-painted details nodding to the brand's iconic red wax seal. Pacula said: "Maker's Mark has a very intentional approach to craft, and I wanted to mirror that in this body of work. I spent time in each city, immersed in its rhythm and atmosphere, and translated those impressions into expressive visuals that bring each label — and each place — to life." "Travel retail continues to be a key channel for premium spirits, as consumers increasingly seek exclusive and experience-led purchases during their journey, " commented Ashish Sagar, Interim General Manager, Global Travel Retail at Suntory Global Spirits. " With the brand's distinctive craftsmanship, the Maker's Mark Artist Series creates a collectible proposition that truly stands out in airport retail." The Maker's Mark Artist Series – City Edition will be available beginning in Sydney (SYD), Melbourne (MEL), Singapore (SIN) and Seoul (ICN) airports in July, followed by London (LHR, LGW, STN) and Paris (CDG) in August. The series will continue to roll out in Dubai (DXB), Delhi (DEL), Mumbai (BOM), and in the United States in New York (JFK) and Los Angeles (LAX) in September. For more information, visit www.makersmark.com . ABOUT MAKER'S MARK Maker's Mark® is the iconic handmade Kentucky bourbon driven by a vision for better flavor and a better world. In 1953, founders Margie and Bill Samuels, Sr. broke from tradition—burning the family's 170-year-old recipe to create a bold, balanced bourbon made with soft red winter wheat for signature sweetness and creaminess. From the start, the Samuels went to remarkable lengths to craft uncompromisingly delicious bourbon—a perfectly unreasonable spirit that endures today. Every bottle is still hand-dipped in red wax, every barrel rotated by hand and every decision guided by the brand's higher purpose. Staying true to its founders' vision, Maker's Mark has expanded its portfolio with award-winning, super-premium expressions, including Maker's Mark 46, Cask Strength, and Cellar Aged, as well as Private Selection, the brand's custom barrel program. In 2025, the distillery debuted Star Hill Farm Whisky. Named World's Best Wheat Whisky and the first to earn Estate Whiskey certification, Star Hill Farm Whisky inspired the Maker's Mark Regenerative Alliance, a bold commitment to advance regenerative farming beyond its business. Maker's Mark is proud to be both B Corp and Regenified Certified – milestones driven by the sustainability leadership at Star Hill Farm, home of the Maker's Mark Distillery, which strives to be the most endearing, culturally rich and environmentally responsible homeplace in the world. Alexandra Pacula ( b. 1979, Poland) is a cityscape and landscape artist, focusing on realism through oil painting. She received her BFA from the Mason Gross School of the Arts at Rutgers University, completing her MFA in painting and drawing at Montclair State University in New Jersey. Pacula is fascinated by light and its transformations. About her painting she says, "My work investigates a world of visual intoxication; it captures moments of enchantment, which are associated with urban nightlife... I recreate the feeling of dizziness and confusion by letting the paint blur and allowing shapes to dissolve. I suggest motion in order to slow down the scene and capture the fleeting moments, which tend to be forgotten." Represented by Gallery Henoch in New York, Alexandra Pacula's work is in several public and corporate collections, including Harvard Law School, PACE University, and Tohokushinsha Film Corporation in Tokyo. She has frequently exhibited in solo and group exhibitions. Media Contact: Gabrielle Tutheridge, Articulate makersmark@toarticulate.com WE MAKE OUR WHISKY CAREFULLY. PLEASE ENJOY IT THAT WAY. Maker's Mark® Kentucky Straight Bourbon Whisky, 56.65-59.4% Alc./Vol. ©2026 Maker's Mark Distillery, Inc., Loretto, KY. Alexandra Pacula, artist behind the Maker's Mark Artist Series City Edition, with her original artwork.
2026-07-15 10:00:00

IBM Launches New Power Systems and Software Built for Enterprises to Address Risk, Productivity, and Flexibility
New IBM Power Autonomous Operations software identifies and resolves capacity constraints up to 15x 1 faster than manually performing the operation IBM BobTM Premium Package for i helps accelerate application development on IBM i Entry-level Power S1112 server helps enterprises innovate at every scale ARMONK, N.Y. , July 15, 2026 /PRNewswire/ -- IBM (NYSE: IBM ) today announced IBM Power Autonomous Operations, an AI agent that can help continuously monitor Power systems and autonomously resolve issues to keep operations running smoothly. It complements the recently launched IBM BobTM Premium Package for i, which brings agentic-driven software designed to accelerate application development on IBM i. These capabilities can accelerate building modern applications so enterprises can innovate at the pace required by their business. Additionally, the entry-level Power S1112 server provides a new compact, efficient option powerful enough to run AI inference locally. IBM Power S1112, a 1-socket, half-wide Power11 server. (Image credit: Thomas Prior for IBM) IBM Power has long been IBM's platform for mission-critical enterprise workloads. As AI becomes part of that critical infrastructure, Power is built to support it. IBM introduced Power11 last year as autonomous IT for the AI era, built for availability, resiliency, and scale across on-premises and IBM Cloud environments. IBM Power Virtual Server is a fully managed cloud service on which enterprises can run AIX, IBM i and Linux workloads while offloading much of the routine management for system operations. Now, IBM is embedding autonomous IT across the Power platform, from code to runtime, with new capabilities and systems. According to the IBM IBV 2026 Tech Leader Study: Building the IT foundation for agentic AI at scale, by 2027, enterprises expect to deploy an average of 1,661 AI agents—a 38% increase. At that rate, tech leaders are tasked with managing hundreds of thousands of autonomous decisions daily. And manual governance can't keep up with that math. 2 Additionally, according to the IBM Institute for Business Value, Enterprise 2030 study, AI is changing what companies do and how they do it. 3 Closing that gap in scale requires an IT foundation that can run and optimize itself while teams focus on innovation. These newly announced capabilities utilize AI agents to build automation directly into IBM Power across operations, security, and application development so clients can innovate with AI while prioritizing control and resilience. Power Autonomous Operations automates running and optimizing systems, with an embedded agent that lets teams manage Power through simple chat-style prompts. IBM Bob Premium Package for i makes IBM i development accessible to a broad range of engineers, expanding who can build and modernize their applications on the platform. "Enterprises should not need to choose between moving at the speed of AI and keeping their systems stable and secure," said Hillery Hunter, General Manager for IBM Power and CTO, IBM Infrastructure . "We're making Power increasingly self-operating, so the routine work of helping to keep systems available, optimized, and secured can happen autonomously, and our clients' teams can spend their time on innovation instead of upkeep. That's how a business scales AI with control and resilience." IBM Power S1112: Extending the Capabilities of Power Servers As enterprises push AI workloads beyond the data center, the IBM Power S1112 is a new one-socket Power11 system built for compact on-prem deployment. The S1112 runs AI workloads locally using Power11 on-chip Matrix Math Acceleration (MMA) for faster inferencing. Power S1112 offers 2x better core performance versus Power S914 4 and 3x better core performance versus Power S814 5 — with up to 69% greater energy efficiency than the S914 6 . To provide clients with the right level of support for this new system, IBM Technology Lifecycle Services is introducing IBM Power Expert Care Premium Essentials, a new incident-focused support tier available exclusively for the Power S1112. Premium Essentials delivers priority access to IBM experts, accelerated response, and intelligent support automation. IBM Power Autonomous Operations: Managing Infrastructure Through Conversation IBM Power Autonomous Operations resolves capacity constraint issues up to 15x faster than manual intervention 7 . Today's enterprise systems can seem to demand constant attention, but manual operations management can make it difficult to manage. IBM Power Autonomous Operations redefines this model by automating and optimizing day-to-day operations across the IBM Power environment. An embedded AI agent that enables natural, conversational interaction can help teams to manage, tune, and streamline their environments without relying on deep domain expertise for every task. The result is a resilient, self-optimizing infrastructure architected to reduce operational burden while accelerating performance and uptime. IBM Bob Premium Package for i: Making IBM i Development Accessible to More Engineers IBM i is a fully integrated operating system that remains a vital part of the core business of many companies across major industries, yet modernizing IBM i applications has historically required specialized skills for RPG applications. To help address this challenge, IBM Bob is an AI-powered development assistant that offers an agentic SDLC experience for enterprise developers. IBM Bob Premium Package for i is engineered to provide built-in support for IBM i conventions and patterns across the full development lifecycle, to help engineers make changes faster, onboard sooner, and evolve applications while prioritizing team capacity along the way. From understanding complex code to moving modernization and AI projects forward, IBM Bob can expand the pool of developers who improve the IBM i applications that organizations depend on every day. Early adopters are already seeing results: Heartland Co-Op estimates 60% faster time for new-to-platform developers to understand complex applications. 8 Client Momentum Clients and partners are already running IBM Power on premises and in the cloud, drawn by its performance, resilience, and hybrid flexibility: "For a business like ours, reliability and simplicity matter because our customers depend on us every day. IBM Power and IBM i have consistently delivered the stability and security we need to support our operations with confidence. And that continues with the introduction of IBM Bob and the IBM Power S1112. What excites me most about the new Power S1112 is the ability to do more with less through increased capacity, energy efficiency, and the growing focus IBM has on automation, making systems easier to manage for small and midsized businesses. We are also excited about how IBM Bob for IBM i can help our team accelerate modernization by quickly interpreting older RPG code, tracing field logic, generating documentation, and making decades of system knowledge easier to understand and act on. Together, IBM Power, IBM i, and IBM Bob give us a forward-looking foundation to modernize with confidence while continuing to deliver the reliability our business depends on." Jasmine Kaczmarek, vice president of technology, M.R. Williams. "What I noticed about IBM Bob almost immediately was the level of detail provided as compared to other AIs. I like using AI to build and execute plans for specific projects. Given the exact same prompt, Bob's planning was always 10-fold more detailed than other AIs. More specifics, more details, and provided a better understanding of the steps through the project from beginning to end." Bob Richardson, ERP Support Analyst, Wynne Systems, Inc. "The new IBM Power S1112 provides us with the flexibility to expand beyond traditional workloads and explore new AI opportunities by running Linux partitions alongside our IBM i environment," said Andy Buchholtz, Owner, Innovative Software Solutions. "Combining that flexibility with the security, reliability, and resilience we trust from the IBM Power platform gives us confidence as we continue to innovate and modernize our business." "We're no longer reacting to weather. We're prepared for it," said Chad Simpson, CIO, City Home. "Our infrastructure is built to keep the business running, no matter what. We've honed our process to perform role swaps every quarter, and this capability gives us great confidence in our business continuity posture. It's a powerful thing, and it's all thanks to IBM Cloud and Power Virtual Server." Availability IBM Power S1112 is expected to be generally available on July 24, 2026, IBM Power Autonomous Operations is expected to be generally available on September 23, 2026, and IBM Bob Premium Package for i was made generally available on June 24, 2026. To learn more, visit ibm.com/power. Statements regarding IBM's future direction and intent are subject to change or withdrawal without notice and represent goals and objectives only. About IBM IBM is a leading provider of global hybrid cloud and AI, and consulting expertise. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Thousands of government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM's hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM's breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and consulting deliver open and flexible options to our clients. All of this is backed by IBM's long-standing commitment to trust, transparency, responsibility, inclusivity and service. Additional Sources Power S1112 and autonomous IT capabilities blog IBM Power S1112 product page IBM Institute for Business Value Enterprise 2030 study Media contact: Sarah Fraser IBM Infrastructure Communications sarah.fraser@ibm.com 1 Disclaimer 1: The performance and capacity management efficiency claim is based on IBM internal testing conducted in a controlled, representative IBM Power infrastructure environment consisting of eleven IBM Power systems. Capacity thresholds and alerting policies were preconfigured prior to test execution. Under this configuration, the manual operational process entailed—navigating to the performance dashboard for each system, exporting performance data to CSV/XLS format, reviewing and analyzing the data to identify required capacity adjustments, and implementing the changes—required on average 52.59 minutes to detect and resolve capacity‐related conditions across the eleven systems. In a comparable scenario, IBM Power Autonomous Operations, which includes alert ingestion and AI-based, agent-driven diagnostic analysis producing recommended and remedial actions with human-in-the-loop approval to remediate, completed the same process in on average 3.33 minutes. 2 https://www.ibm.com/thought-leadership/institute-business-value/en-us/c-suite-study/cxo 3 https://www.ibm.com/thought-leadership/institute-business-value/en-us/report/enterprise-2030 4 Based on published CPW results comparing Power S1112/4 core to IBM Power S914/4 core. Valid as of 7/14/2026 and available at: https://www.ibm.com/downloads/documents/us-en/10c31775c5d40fed 5 Based on published CPW results comparing Power S1112/4 core to IBM Power S814/4 core. Valid as of 7/14/2026 and available at: https://www.ibm.com/downloads/documents/us-en/10c31775c5d40fed 6 Based on system capability of Power S1112/10c performance 291,300E CPW (extrapolated from 116,500 CPW for 4-cores) @ 540E Watts (539 Performance/Watt) compared to Power S914/8cperformance of 122,500 CPW @ 383 Watts (319 Performance/Watt); 539 / 319 = 1.69 more Performance/Watt 7 Disclaimer 1: The performance and capacity management efficiency claim is based on IBM internal testing conducted in a controlled, representative IBM Power infrastructure environment consisting of eleven IBM Power systems. Capacity thresholds and alerting policies were preconfigured prior to test execution. Under this configuration, the manual operational process entailed—navigating to the performance dashboard for each system, exporting performance data to CSV/XLS format, reviewing and analyzing the data to identify required capacity adjustments, and implementing the changes—required on average 52.59 minutes to detect and resolve capacity‐related conditions across the eleven systems. In a comparable scenario, IBM Power Autonomous Operations, which includes alert ingestion and AI-based, agent-driven diagnostic analysis producing recommended and remedial actions with human-in-the-loop approval to remediate, completed the same process in on average 3.33 minutes. 8 Heartland Co-op Modernizes Grain Operations with IBM i and IBM Bob IBM PowerS1112, tower chassis form factor. (Image credit: Thomas Prior for IBM) IBM Corporation logo.
2026-07-15 10:00:00

苗栗東河村風災成孤島 部落青年射箭搭繩傳物資
Newtalk新聞 (中央社記者魯鋼駿苗栗縣13日電)颱風巴威造成苗栗縣苗21線多處崩塌,東河村由於交通中斷成為孤島。為解當地物資之急,鹿場部落青年以弓箭將細繩射向對岸,搭起繩索傳遞物資給鹿湖、鹿山部落。 苗栗南庄鄉公所應變中心今天表示,苗21線石壁橋到神仙谷路段沿線多處崩塌,交通中斷,鹿湖部落12人無法聯外,目前狀況良好,但須空投民生物資。 無黨籍苗栗縣議員楊文昌(Baiho.Watan)告訴中央社記者,鹿場部落有雜貨店,物資較不缺乏,部落青年用弓箭將細繩索射向對岸,讓鹿湖及鹿山部落青年接收,以分配及傳遞物資。 楊文昌說,東河村聯外道路多處嚴重坍塌,不確定何時可搶通,幸當地電力沒中斷,還可透過手機聯繫,如果有相關物資需求可及時提供。 部落青年說,由於沒拋繩槍,弓箭才能射30公尺以上距離,將細繩索綁在箭上射向對岸,兩側固定後作為物資運補傳遞動線,只要接到對岸青年致電求助,就會再次傳遞物資。(編輯:李明宗)1150713 延伸閱讀: 藍白立法院預算一毛未刪 民進黨批雙標:惡搞國家、只顧自肥 快訊》2縣市大雷雨狂炸!氣象署示警慎防雷擊 (影)曼谷酒吧大火27死63傷 涉及旅遊外籍人士身份辨認困難 台股周報》台積電法說倒數 台股能否站穩46K關鍵曝光 快訊》7/13 降雨特報!外出請注意,留意路面積水
2026-07-13 06:55:10

传奇娱乐和华纳兄弟影业推出沙丘:第三部分预告片和幕后花絮,展示阿布扎比的阿拉基斯
阿联酋阿布扎比 2026年7月9日 /美通社/ -- 传奇娱乐( Legendary Entertainment ) 和华纳兄弟影业( Warner Bros. Pictures )公布了《沙丘:第三部分》( Dune: Part Three )的官方新预告片,标志着丹尼斯•维伦纽夫( Denis Villeneuve的奥斯卡获奖传奇片史诗般的最后一章。 (L-r) Director/Writer/Producer DENIS VILLENEUVE and Zendaya on the set of Warner Bros. Pictures and Legendary Pictures’ action adventure “DUNE: PART THREE,” in the Liwa Desert, Abu Dhabi. A Warner Bros. Pictures release. Photo by Niko Tavernise. 阿布扎比电影委员会( ADFC )还分享了在阿布扎比原始的《沙丘利瓦沙漠:第三部分》( Liwa Desert for Dune: Part Three )拍摄的全新幕后花絮,由Denis Villeneuve )与演员和工作人员在现场演出,并展示了委员会与传奇在过去七年里在所有三部电影中的持续合作关系。 在整个系列中, LIWA广阔而超凡脱俗的风景让Arrakis栩栩如生,并帮助定义了一些最具标志性的电影时刻。 《沙丘:第三部分》为Denis Villeneuve的三部曲带来了惊人的结局,故事发生在保罗•阿特雷德( Paul Atreides )夺取帝国后近二十年。 现在,作为一个无情的皇帝,保罗必须面对他统治的后果,因为老盟友回来了,可怕的新威胁出现了,背叛潜伏在每一个阴影中。 保罗被帝国崩溃的幻象和他失散已久的爱情的再现所困扰,被卷入了一场彻头彻尾的阴谋,而查尼则处于其展开的奥秘的核心。 随着叛乱的酝酿和敌人的逼近,保罗必须面对权力的真正代价和他最爱的人的命运。 规模宏大,情感亲密,《沙丘:第三部分》为我们这个时代的决定性史诗之一提供了强大而富有诗意的结论。 在《沙丘》( 2021年)和《沙 丘:第二部分》( 2024年)中建立的视觉遗产的基础上,阿布扎比引人注目的沙漠景观再次在将阿拉基斯的世界变为现实中发挥着核心作用。 "有机会再次与《沙丘:第三部分》令人难以置信的演员和工作人员合作,阿布扎比的《利瓦沙漠》主演丹尼斯•维伦纽夫( Denis Villeneuve的最终作品《阿拉基斯》( Arrakis ) ,这对阿布扎比的整个创意生态系统来说,确实是一个痛苦而关键的时刻。 超过600名阿联酋人参与了为期31天的拍摄,从人群场景中的6名实习生和38名居民,到206名当地工作人员和336名来自我们更广泛的创意产业的人,包括餐饮服务商和司机,《沙丘:第三部分》的影响是巨大的。 阿布扎比电影委员会负责人Sameer Al Jaberi表示: "与世界其他地区一样,我们现在正踏上令人兴奋的倒计时之旅,直至12月16日,届时我们将看到许多个人努力的成果,这些努力将联合起来, 为传奇娱乐公司提供无缝合作。" "回到阿布扎比的沙丘利瓦沙漠:第三部分从未怀疑过。 我想不出世界上还有哪个地方能够提供如此令人惊叹的图像,以及我们从阿布扎比电影委员会和我们的合作伙伴那里获得的所有三部电影的支持。 阿布扎比的人员、工作人员和资源使一项极其艰巨的任务感到舒适和轻松,我们的演员和工作人员对细节的关注度非常出色。"传奇娱乐公司实体制作执行副总裁Herb Gains表示。 DUNE :第三部分得到阿布扎比创意媒体管理局( CMA )和阿布扎比电影委员会的支持, Image Nation Abu Dhabi担任制作合作伙伴, Epic Films担任本地制作服务提供商。 制作还受益于阿布扎比的现金返还返还计划和206名技术娴熟的当地工作人员,其中包括12名特技表演者,还有336名当地承包商和司机,凸显了该酋长国作为大型国际电影制作首选目的地的持续增长。 在阿布扎比为期31天的拍摄,包括在艾因(Al Ain)的两天拍摄,还需要38人的协助,以支持镜头内的人群场景,而 6名年轻有才的实习生则在镜头外支持制作角色。 《沙丘:第三部分》特技表演者Mohamed F Mostafa表示: "与一些世界领先的电影创意人士合作,能够将一个国家在沙漠环境中和谐工作的真实性带给了我作为阿联酋人的极大自豪感,现在,随着世界再次在屏幕上看到阿拉基斯,能够在银幕上看到我们美丽的当地风 景和才华 , 这将以这种自豪感为基础。 " "传奇娱乐与阿布扎比电影委员会之间的持久关系跨越了十多年,反映了对支持世界级制作的共同承诺。 在此期间,阿布扎比已被证明是一个值得信赖的合作伙伴,提供在全球范围内成功执行生产所需的专业知识、基础设施和协作。 《沙丘》三部曲证明了这种关系的力量,我们为共同取得的成就感到自豪, " 传奇娱乐公司运营与企业开发执行副总裁 Sam Kozhaya 表示。 《沙丘:第三部分》由Denis Villeneuve Villeneuve )执导,维伦纽夫( Villeneuve )和布莱恩• K •沃恩( Brian K. Vaughan )编剧,改编自弗兰克•赫伯特( Frank Herbert )的小说,为维伦纽夫( Villeneuve ) 这部电影由Timothée Chalamet、Zendaya、Jason Momoa、Florence Pugh、Rebecca Ferguson、Isaach De Bankolé、Charlotte Rampling、Anya Taylor-Joy、Robert Pattinson和Javier Bardem主演,并由新人Nakoa-Wolf Momoa和Ida Brooke主演。 华纳兄弟图片和传奇图片呈现传奇图片制作,Denis Villeneuve的电影,沙丘:第三部分。 这部电影仅于2026年12月18日在北美的影院和IMAX ®上映,并于2026年12月16日开始在国际上映,由华纳兄弟影业在全球发行,由传奇东方在中国发行。 (L-r) TIMOTHÉE CHALAMET and Director/Writer/Producer DENIS VILLENEUVE on the set of Warner Bros. Pictures and Legendary Pictures’ action adventure “DUNE: PART THREE,” in the Liwa Desert, Abu Dhabi. A Warner Bros. Pictures release. Photo by Niko Tavernise. Director/Writer/Producer DENIS VILLENEUVE on the set of Warner Bros. Pictures and Legendary Pictures’ action adventure “DUNE: PART THREE,” in the Liwa Desert, Abu Dhabi. A Warner Bros. Pictures release. Photo by Niko Tavernise. Legendary Entertainment and Warner Bros. Pictures Unveil Dune: Part Three Trailer and Behind-the-Scenes Images Showcasing Abu Dhabi as Arrakis
2026-07-08 20:08:00

Legendary Entertainment 與 Warner Bros. Pictures 正式發佈《沙丘瀚戰:第三章》預告片及幕後花絮照,展現阿布扎比化身厄拉科斯的壯闊面貌
阿聯酋阿布扎比 2026年7月9日 /美通社/ -- Legendary Entertainment 與 Warner Bros. Pictures 正式發佈 《沙丘瀚戰:第三章》 全新官方預告片,為 Denis Villeneuve 屢獲奧斯卡金像獎殊榮的史詩系列寫下磅礴終章。 (L-r) Director/Writer/Producer DENIS VILLENEUVE and Zendaya on the set of Warner Bros. Pictures and Legendary Pictures’ action adventure “DUNE: PART THREE,” in the Liwa Desert, Abu Dhabi. A Warner Bros. Pictures release. Photo by Niko Tavernise. Abu Dhabi Film Commission (ADFC) 亦分享了 《沙丘瀚戰:第三章》 在阿布扎比原始純淨的利瓦沙漠取景時拍攝的全新幕後花絮照,相中可見 Denis Villeneuve 與演員及製作團隊在拍攝現場,並展現該委員會與 Legendary 過去七年來在三部電影中延續的合作關係。 在整個系列中,利瓦沙漠遼闊而恍如異世的景觀令厄拉科斯栩栩如生,亦成就了其中一些最具標誌性的銀幕時刻。 《沙丘瀚戰:第三章》 為 Denis Villeneuve 的三部曲寫下震撼人心的終章,故事發生在 Paul Atreides 奪取帝國統治權近二十年後。 如今身為冷酷無情的皇帝,Paul 必須承受其統治帶來的代價,昔日盟友歸來、恐怖的新威脅浮現,而背叛亦無處不在。 Paul 因帝國覆亡的幻象及失散多年的摯愛再度現身而飽受困擾,並被捲入一場牽連甚廣的陰謀,而這個逐步揭開的謎團正以 Chani 為核心。 隨着叛亂醞釀、敵人步步進逼,Paul 必須直面權力的真正代價,以及他最愛之人的命運。 《沙丘瀚戰:第三章》 格局宏大而情感細膩,為我們這個時代極具代表意義的史詩鉅作,畫下鏗鏘有力而詩意盎然的句號。 承襲 《沙丘瀚戰》 (2021) 及 《沙丘瀚戰:第二章》 (2024) 所奠定的視覺傳承,阿布扎比壯闊的沙漠景觀再次發揮核心作用,令厄拉科斯世界栩栩如生。 Abu Dhabi Film Commission 主席 Sameer Al Jaberi 評論道:「 「能夠再次與 《沙丘瀚戰:第三章》 的一眾出色演員及製作團隊合作,並讓阿布扎比的利瓦沙漠在 Denis Villeneuve 的系列終章中化身厄拉科斯,對阿布扎比整個創意產業生態系統而言,確實是意義深遠且舉足輕重的時刻。 為期 31 天的拍攝,動員了超過 600 名駐阿聯酋人員參與,從 6 名實習生、38 名擔任群眾演員的居民,到 206 名本地劇組人員,以及來自廣泛創意產業的 336 名人員(包括餐飲和司機), 《沙丘瀚戰:第三章》 帶來的影響極為深遠。 我們與世界其他地方的人一樣,現正踏上令人萬分期待的倒數之旅,期待 12 月 16 日到來,屆時將親睹眾志成城的豐碩成果,這份匯聚各方心血的無間合作,成就了與 Legendary Entertainment 的無縫協作。」 Legendary Entertainment 實體製作執行副總裁 Herb Gains 表示: 「 重返阿布扎比的利瓦沙漠拍攝 《沙丘瀚戰:第三章》 ,從來都是毋庸置疑的選擇。 我想不到世上還有哪個地方,既能呈現如此震撼的畫面,又能像 Abu Dhabi Film Commission 及當地合作夥伴一樣,在三部電影的製作過程中一直給予我們鼎力支持。 阿布扎比的團隊、劇組人員及資源配套,令這項艱鉅非常的任務化為舉重若輕的從容體驗,其對演員及製作團隊那份一絲不苟的專注及體貼入微的關懷,更是令人難忘。」 《沙丘瀚戰:第三章》 獲 Creative Media Authority Abu Dhabi (CMA) 及 Abu Dhabi Film Commission 支持,並由 Image Nation Abu Dhabi 擔任製作夥伴,Epic Films 則擔任本地製作服務供應商。 此製作亦受惠於阿布扎比的現金回贈計劃,並有 206 名藝超群的本地劇組人員參與,包括 12 名特技演員,另有 336 名本地承包商及司機加入,突顯該酋長國作為大型國際電影製作首選拍攝地的地位持續提升。 為期 31 天的阿布扎比拍攝行程(包括在艾因的 2 天),亦動員了 38 名人員協助處理幕前的群眾場面,另有 6 名才華出眾的年輕實習生參與幕後製作工作。 《沙丘瀚戰:第三章》特技演員 Mohamed F Mostafa 表示 : 「能夠與一些全球頂尖的電影創作人才合作,並真實呈現一個國家如何在沙漠環境中和諧運作,令身為阿聯酋人的我深感自豪。如今,當世界再次在銀幕上看到厄拉科斯,我們美麗的本地景觀與人才亦得以登上銀幕,令我更感自豪。」 Legendary Entertainment 營運與企業發展執行副總裁 Sam Kozhaya 表示: 「Legendary Entertainment 與 Abu Dhabi Film Commission 之間歷久彌堅的合作關係已跨越十多年,體現雙方對支持世界級製作的共同承諾。 多年來,阿布扎比已證明自己是可靠的合作夥伴,提供在全球層面成功執行製作所需的專業技術、基礎建設及協作配套。 《沙丘瀚戰》 三部曲充分證明了這段合作關係的深厚實力,我們亦為共同取得的成果感到自豪。」 由 Denis Villeneuve 執導,並與 Brian K. Vaughan 共同編劇, 《沙丘瀚戰:第三章》 改編自 Frank Herbert 所著的小說,為 Villeneuve 的三部曲帶來史詩式結局。 電影主演陣容包括 Timothée Chalamet、Zendaya、Jason Momoa、Florence Pugh、Rebecca Ferguson 及 Isaach De Bankolé,另有 Charlotte Rampling、Anya Taylor-Joy、Robert Pattinson 及 Javier Bardem 參演,新晉演員 Nakoa-Wolf Momoa 與 Ida Brooke 亦會亮相。 Warner Bros. Pictures 與 Legendary Pictures 呈獻,Legendary Pictures 製作,Denis Villeneuve 執導的 《沙丘瀚戰:第三章》 。 本片將於 2026 年 12 月 18 日在北美地區僅於戲院及 IMAX ® 上映,並於 2026 年 12 月 16 日起在其他國際市場上映;本片由 Warner Bros. Pictures 負責全球發行,中國地區則由 Legendary East 發行。 (L-r) TIMOTHÉE CHALAMET and Director/Writer/Producer DENIS VILLENEUVE on the set of Warner Bros. Pictures and Legendary Pictures’ action adventure “DUNE: PART THREE,” in the Liwa Desert, Abu Dhabi. A Warner Bros. Pictures release. Photo by Niko Tavernise. Director/Writer/Producer DENIS VILLENEUVE on the set of Warner Bros. Pictures and Legendary Pictures’ action adventure “DUNE: PART THREE,” in the Liwa Desert, Abu Dhabi. A Warner Bros. Pictures release. Photo by Niko Tavernise. Legendary Entertainment and Warner Bros. Pictures Unveil Dune: Part Three Trailer and Behind-the-Scenes Images Showcasing Abu Dhabi as Arrakis
2026-07-08 19:58:00

鄭麗文:台灣表面光鮮亮麗 實際根、心都快爛掉
Newtalk新聞 國民黨主席鄭麗文今(3日)出席「婦女政策推動發展文教基金會115年度志工大會」,向國民黨的婦女志工長表達感謝。鄭麗文在期間感嘆,表面上看起來,台灣似乎光鮮亮麗,股市都快要到5萬點,依舊是世人羨慕、欣欣向榮的地方;但是,台灣「根、心都快要爛掉了」,這才是今天台灣真正的現實,也是令人憂慮與焦慮的地方。 鄭麗文表示,從今天的國民中央黨部就可以知道,國民黨被民進黨追殺、團滅,黨產被沒收,簡直就是要刨掉國民黨的命根,恨不得國民黨下一秒就從地表消失。但是,國民黨仍然堅定走到今天,而且越走越穩、越走越旺。 鄭麗文表示,她知道許多黨工與基層同志真的委屈了。過去這段時間,因為國民黨遭到打壓,沒有辦法真正保護大家,讓民進黨居然可以動用司法,對國民黨做出無理、過分的騷擾、打壓、追殺與迫害,讓他們活在2026年的台灣,感覺到非常悲哀。 鄭麗文提到,台灣能有「護國神山」與高科技產業,大家當然與有榮焉。但沒有國民黨,就沒有台積電;沒有台灣的護國神山,就沒有高科技產業,但這畢竟是上個世紀70年代、80年代國民黨留下的基礎,如今已經過了40、50年,當台灣還在這樣的庇護下,許多人對台灣未來其實非常茫然。 鄭麗文再提到,當前兩岸關係非常緊張,但台灣每天內耗、惡鬥。她認為,台灣不能沒有危機感。她說,不能等到最後一刻來不及時才喊和平;接下來兩年對台灣至關重要,國民黨一定要努力拿回政權,大家身上的委屈與不甘才有辦法撥亂反正,司法才能回歸正常。 鄭麗文表示最後,接下來有兩場關鍵大戰,就是2026年與2028年。2026年要穩住陣腳,也要重點突破,希望南部不要永遠都是民進黨的江山;2028年也不到兩年,時間非常快;她希望兩年之後藍天再現,國民黨重新帶領台灣撥亂反正。 延伸閱讀: 還原拍桌經過!吳沛憶怒批翁曉玲「複製貼上審預算」:第二輪還要再刪 懶人包》7月新制一次看:職場霸凌新法上路、線上申換護照更方便 鄭麗文遭批敗票 王金平:調整一下應會讓國民黨團結 再怨訪美成果遭打壓 鄭麗文:沒引起應有注意、我在美國見到大咖朋友 鄭麗文喊創護國神山群!林濁水酸:恭喜國民黨有千年不一見大天才
2026-07-03 03:47:14

Trane Launches HSWE Magnetic Bearing Chiller to Advance Data Center Cooling Across Asia Pacific
SHANGHAI , July 2, 2026 /PRNewswire/ -- Trane – by Trane Technologies (NYSE: TT), a global climate innovator, announced the launch of the HSWE magnetic bearing centrifugal chiller, developed specifically for the Asia Pacific market. Designed to tackle the most demanding cooling applications, especially data centers, the HSWE combines ultra-high efficiency, reliable performance and intelligent controls, further strengthening Trane's premium chiller portfolio across the region. "The launch of the HSWE marks an important milestone for Trane Technologies in Asia Pacific, highlighting our advanced, ground-up innovation in the region," said Bruce Zhongping Gu, Vice President, Engineering and Technology, Trane Technologies Asia Pacific. "As a regionally developed water-cooled magnetic bearing technology platform, the HSWE was created specifically to address the evolving needs of customers in Asia Pacific, including the extreme performance demands of modern data centers." Powered by advanced compressor technology and an innovative heat exchanger design, the HSWE achieves a full-load COP of up to 7.3 under China's GB standard and an AHRI IPLV of up to 12.3. With electricity estimated to account for approximately 88.5% of a chiller's total lifecycle cost, its high efficiency can translate into substantial operational savings for building owners and operators. The unit is also designed with readiness for next-generation HFO refrigerants, helping customers in Asia Pacific prepare for evolving sustainability and regulatory requirements. Beyond energy performance, its ultra-quiet operation, with noise levels as low as 73 dB(A), also makes it ideal for noise-sensitive environments such as hospitals and commercial buildings. To support the demanding, year-round operating requirements of data centers, the HSWE offers a cooling capacity range of 500 -1,250 RT for standard applications and 600 to over 1,500 RT for data centers. It also supports a maximum leaving chilled water temperature of up to 35°C, enabling seamless integration with waterside economizer and free cooling systems. In mission-critical environments, fast recovery is essential. The HSWE can restart within 25 seconds after power restoration and achieve full load within two minutes, drastically reducing the risk of server overheating and business interruption. In addition, the HSWE is equipped with the advanced AdaptiViewTM controller, which integrates multiple patented control logics including adaptive control, feedforward control, and variable primary flow compensation. It also marks the successful application of adaptive refrigerant flow control on a centrifugal platform. Together, these capabilities enable precise chilled-water temperature control and stable output under changing loads and variable-flow conditions, supporting the sophisticated energy-saving strategies used in today's high-performance buildings and data centers. About Trane Trane® – by Trane Technologies (NYSE: TT), a global climate innovator – creates comfortable, energy efficient indoor environments for commercial and residential applications. For more information, please visit trane.com . About Trane Technologies Trane Technologies is a global climate innovator. Through our strategic brands Trane® and Thermo King®, and our portfolio of environmentally responsible products and services, we bring efficient and sustainable climate solutions to buildings, homes and transportation. For more on Trane Technologies, visit tranetechnologies.com .
2026-07-02 02:00:00

Chulalongkorn University President Elected Head of Asian Universities Alliance
ASTANA, Kazakhstan , July 2, 2026 /PRNewswire/ -- Professor Dr. Wilert Puriwat, President of Chulalongkorn University , has been elected President of the Asian Universities Alliance (AUA) for the 2027–2029 term, becoming the first Thai university leader to head the regional alliance. The election was unanimously approved during the AUA Board Meeting 2026, held in early June at Nazarbayev University in Astana as part of the AUA Presidents Forum 2026. Chulalongkorn University President Elected Head of Asian Universities Alliance The forum was held under the theme "Shaping Future Universities: Industry Engagement and Governance Innovation," bringing together university presidents and senior executives from leading institutions across Asia to discuss the future direction of higher education and university governance. Founded in 2017, the AUA comprises 15 leading universities from countries and economic regions across Asia. Its members include Tsinghua University, Peking University, the National University of Singapore, the University of Tokyo, Seoul National University, Universiti Malaya, and other prominent institutions. The alliance serves as a platform for cooperation in higher education, research, innovation, and academic exchange. It was established to strengthen collaboration in higher education, science, technology, and economic development across Asia while enhancing the region's role on the global stage. Chulalongkorn University is the alliance's only founding member from Thailand. Dr. Wilert's election marks the first time a Thai institution has assumed the organization's top leadership position. During the forum, Dr. Wilert presented his vision on "Future University Governance Models," outlining approaches to help universities adapt to a rapidly changing global environment. His presentation focused on governance strategies designed to strengthen institutional resilience, innovation, and engagement with industry and society. The AUA appointment marks a significant milestone for Chulalongkorn University and Thailand's higher education sector, placing a Thai university leader at the helm of a network that brings together some of Asia's most prominent institutions. Dr. Wilert currently serves as President of the Council of University Presidents of Thailand (CUPT) , President of the Association of Southeast Asian Institutions of Higher Learning (ASAIHL) , and President of the Asia-Europe Meeting Lifelong Learning Hub (ASEM LLL Hub) for the 2025–2030 term. Founded in 1917, Chulalongkorn University is Thailand's oldest university and will celebrate its 110th anniversary next year. Read more at https://www.chula.ac.th/en/news/411888/ Media Contact: Chula Communication Center Email: Pataraporn.r@chula.ac.th
2026-07-02 02:00:00

Agoda Recommends the Best Destinations to Beat the Heat This Summer
SINGAPORE , July 2, 2026 /PRNewswire/ -- As temperatures rise across Europe and Asia, digital travel platform Agoda invites travelers to escape the sweltering heat with a curated list of cool retreats across the Asia-Pacific region. From the snow-dusted peaks of New Zealand to the breezy highlands of Malaysia, Agoda's selection offers refreshing getaways where travelers can enjoy crisp weather and unique experiences. Agoda's curated list of destinations promises a summer escape that's anything but ordinary. New Zealand Queenstown and Wellington offer the perfect backdrop for travelers seeking a chilly escape. Queenstown, known as the adventure capital, provides an alpine winter wonderland with temperatures ranging from 9°C (48°F) to -2°C (28°F) in July and August, ideal for skiing enthusiasts. Meanwhile, Wellington, with temperatures between 14°C (57°F) to 7°C (45°F), invites visitors to explore its cultural offerings and coastal charm, making it a perfect spot to cool off. Australia Melbourne and Hobart in Tasmania present urban and wilderness experiences with crisp weather. Melbourne, with its vibrant culture and dining scene, maintains a cool 14°C (57°F) to 7°C (45°F), perfect for those seeking a refreshing city break. Hobart, a historic port city, serves as a gateway to Tasmania's wilderness, with temperatures from 11°C (52°F) to 3°C (37°F), offering a serene escape into nature. Japan Sapporo and Hakodate in Hokkaido offer a mild summer with temperatures between 22°C (72°F) to 17°C (63°F). Sapporo, famous for its beer and lavender fields, and Hakodate, known for its seafood and mountain views, provide a refreshing break from the heat, perfect for those looking to chill out in style. Malaysia The Cameron Highlands and Genting Highlands offer cooler climates with temperatures ranging from 25°C (77°F) to 15°C (59°F). These highland retreats are perfect for exploring tea plantations and enjoying mountain resort activities, providing a cool breeze amidst the tropical heat. India Manali and Shimla, with temperatures between 25°C (77°F) to 15°C (59°F), are ideal for adventure and scenic beauty. Manali is an adventure hub, while Shimla offers historic charm and accessibility from Delhi, both providing a refreshing escape from the summer heat. Andrew Smith, Senior Vice President, Supply at Agoda shared, "As temperatures soar this summer, Agoda is your ticket to finding the perfect destination to cool off. Whether you're hitting the slopes in Queenstown or enjoying the crisp mountain breeze in the Cameron Highlands, we're here to help you escape the heat and discover the region's most refreshing retreats, with accommodations, flights and activities you can book seamlessly in one platform." Travelers seeking a cool retreat in the summer heat can browse over 6 million holiday properties, along with more than 300,000 activities and over 130,000 flight routes, all of which can be combined in the same booking. Discover the best deals on Agoda's mobile app or visit Agoda.com for more.
2026-07-02 02:00:00

MORE YOUNG PEOPLE STRUGGLE WITH HAIR LOSS: REGAINE®* LEADS THE CHARGE FOR HAIR SCIENCE RESEARCH
New findings show hair loss affecting more young people in APAC Social media is driving earlier awareness of hair loss REGAINE ® reaffirms commitment to research and innovation to meet evolving hair loss landscape at the 14 th World Congress of Hair Research (WCHR) Study conducted by renowned Korean professors on the combination use of oral and topical minoxidil shared at WCHR SINGAPORE , July 2, 2026 /PRNewswire/ -- Hair loss is not a condition that exclusively plagues middle-aged men. Findings in recent years show that androgenetic alopecia, more commonly known as hereditary hair loss and also the most common form of hair loss, does affect younger individuals. [1] , [2] Against this backdrop, REGAINE ® continues to spearhead research and innovation to redefine the next generation of hair loss care. Dr. Leona Yip, Consultant Dermatologist, Alopecia Specialist and Fellow of the Australasian College of Dermatologists, Brisbane, Australia The Changing Face of Hair Loss Androgenetic alopecia is characterized by the progressive miniaturization of hair follicles and shortening of the hair growth cycle. [3] It affects up to 80% of men and 50% of women by age 70. [4] Recent evidence has shown that individuals may suffer an early onset of androgenetic alopecia, where hair loss occurs before the age of 30 years old. [1],[2] Dr. Leona Yip, Consultant Dermatologist, Alopecia Specialist and Fellow of the Australasian College of Dermatologists from Brisbane, Australia, said, "In my clinical practice, I am seeing more teenagers and young adults seeking treatment for androgenetic alopecia, sometimes as early as their mid-to-late teens. While genetics remains the primary driver, we now recognize that environmental and lifestyle factors can also influence how early and progressively hair loss presents in predisposed individuals. Factors such as rapid weight loss, psychological stress, UV exposure, pollution, smoking, metabolic health and poor scalp health may all contribute to increased oxidative stress and inflammation around the hair follicle. Increased awareness through social media and improved health literacy also means younger patients are recognizing the signs of hair loss much earlier – creating an important opportunity for earlier intervention and long-term scalp and hair health preservation." "A common misconception is that androgenetic alopecia only affects men. In reality, women are also significantly affected, often with profound impacts on confidence and quality of life. Women accounted for 54% of hair loss treatment users globally. [5] Hormonal changes across a woman's life – particularly during perimenopause and menopause – may unmask or accelerate female pattern hair loss in genetically predisposed individuals," Dr Yip added. The impact of androgenetic alopecia also has far-reaching effects beyond the physical. The appearance of hair loss can impose a significant psychological burden on patients, leading to anxiety, low self-esteem, and severe impairment of personal life and social interaction [6] – placing further emphasis on the importance of early diagnosis and effective treatment. Comprehensive Treatment and Continued Advancement in Hair Loss Research Decades as one of the most researched and clinically tested hair loss treatments worldwide have not slowed its pursuit for advancement as REGAINE ® continues to push the boundaries of what hair regrowth science can achieve. This May, the brand was a platinum sponsor at the 14 th World Congress of Hair Research in Seoul, South Korea, one of the most esteemed gatherings in hair science. At the symposium, Professor Jung Won Shin from Seoul National University and Professor Kwang Seong Choi from Inha University Hospital presented a case sharing on the use of topical minoxidil in combination with oral medications such as finasteride, dutasteride and low-dose minoxidil in treating hair loss. The findings demonstrated the potential of improved hair regrowth after use of combination therapy. In various clinical cases, it was also revealed that adding topical minoxidil to patients already on oral minoxidil can enhance outcomes. [7] Where Every Gain Counts The findings are pivotal, directly impacting both the clinical and consumer community at large. With a deeper understanding of how topical minoxidil – a treatment with established efficacy and favorable safety profile [8] – enhances hair regrowth performance in combination therapy, REGAINE ® continues to innovate with the goal of cementing its place as a trusted first-line hair regrowth option among dermatologists. About The REGAINE ® Brand The REGAINE ® brand is the first topical minoxidil brand FDA-approved to help regrow hair - in both men and women. With 38 years of results and over 47,000 people in clinical trials, REGAINE ® topical minoxidil products help reverse the progression of hereditary hair loss. THIS MEDIA RELEASE IS INTENDED FOR MARKETS WHERE REGAINE ® /ROGAINE ® IS AVAILABLE: AUSTRALIA, MAINLAND CHINA (FTZ), HONG KONG SAR , SOUTH KOREA, AND SINGAPORE * The brand is marketed as Rogaine ® in Mainland China (FTZ) and South Korea [1] Ding Q, Xu YX, Sun WL, Liu JJ, Deng YY, Wu QF, Cao CY, Zhou LB, Lu Y, Fan WX. Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort. J Int Med Res. 2020 Mar;48(3):300060519897190. doi: 10.1177/0300060519897190. PMID: 32188323; PMCID: PMC7105740. [2] Liu LP, Wariboko MA, Hu X, Wang ZH, Wu Q, Li YM. Factors associated with early-onset androgenetic alopecia: A scoping review. PLoS One. 2024 Mar 7;19(3):e0299212. doi: 10.1371/journal.pone.0299212. PMID: 38451966; PMCID: PMC10919688. [3] Ho CH, Sood T, Zito PM. Androgenetic Alopecia. [Updated 2024 Jan 7]. In: StatPearls[Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430924/ [4] Nestor MS, Ablon G, Gade A, Han HW, Fischer DL. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. J Cosmet Dermatol. 2021 Nov 6;20(12):3759–3781. doi: 10.1111/jocd.14537. PMCID: PMC9298335 PMID: 34741573 https://pmc.ncbi.nlm.nih.gov/articles/PMC9298335/ [5] Hair Loss & Growth Treatments and Products Market. Market Growth Reports. Available from: Market Growth Reports [6] Li H, Li W, Zhang J, Liang Q, Zhao Y, Guo Z, Jiang B, Wang Z, Qu Q, An S, Miao Y. Risk factors for androgenetic alopecia: a systematic review and meta-analysis. BMC Public Health. 2026 Jan 28;26(1):1000. doi: 10.1186/s12889-026-26258-y. PMID: 41606541; PMCID: PMC13020014. [7] Kwangsun Choi, Basic therapy for hair loss treatment, the use of topical minoxidil, and case sharing, Proceedings at the World Congress of Hair Research, Seoul, South Korea [8] Hussein, RS, et.al, Applications and efficacy of minoxidil in dermatology. Skin Health Dis. 2024 Nov 24;4(6):e472. doi: 10.1002/ski2.472. PMCID: PMC11608877 PMID: 39624749. https://pmc.ncbi.nlm.nih.gov/articles/PMC11608877/#ski2472-bib-0012
2026-07-02 02:00:00

越來越多年輕人受落髮困擾:REGAINE®*落建引領毛髮科學研究發展
最新研究發現,亞太地區落髮人群日趨年輕化 社交媒體讓大眾更早關注到落髮問題 在第十四屆世界毛髮研究大會 (WCHR) 上, REGAINE® 落建重申將持續深耕研發與創新,應對不斷變化的落髮現狀 韓國知名教授團隊在大會分享口服與外用米諾地爾聯合用藥相關研究成果 新加坡 2026年7月2日 /美通社/ -- 落髮已不再只是中年男性的困擾。近年來的研究表明,雄激素性落髮(即大眾熟知的遺傳性落髮,也是最常見的落髮類型)正逐漸向年輕群體蔓延。 [1],[2] 在此背景下, REGAINE® 落建持續牽頭開展科研與技術創新,打造新一代防脫護髮解決方案。 Dr. Leona Yip, Consultant Dermatologist, Alopecia Specialist and Fellow of the Australasian College of Dermatologists, Brisbane, Australia 落髮問題呈現新態勢 雄激素性落髮的典型特徵為毛囊逐步萎縮,毛髮生長周期縮短。 [3] 該症狀在70歲人群中,男性患病率高達80%,女性達50%。 [4] 最新研究證實,雄激素性落髮正呈現早發趨勢,不少人在30歲前便開始出現落髮症狀。 [1],[2] 來自澳大利亞布裡斯班的皮膚科顧問醫師、落髮專科醫生、Australasian College of Dermatologists(澳大利亞皮膚科醫師學會)院士Leona Yip博士表示:「臨床接診中,前來治療雄激素性落髮的青少年與年輕患者越來越多,有些人甚至在十五六歲到十八九歲就出現這種問題。遺傳仍是致病主因,但我們發現,環境與生活方式也會影響遺傳落髮傾向人群的落髮發病時間及發展速度。快速減重、精神壓力、紫外線照射、環境污染、吸煙、代謝異常以及頭皮狀態不佳等因素,都會加劇毛囊周邊的氧化應激與炎症反應。同時,社交媒體提升了大眾認知、健康素養不斷提高,年輕人群能更早發現落髮跡象,這也為及早干預、長期養護頭皮與毛髮健康創造了有利條件。」 Yip博士補充道:「很多人誤以為雄激素性落髮只發生在男性身上,事實上女性受此問題影響同樣嚴重,落髮往往會極大打擊自信心、降低生活品質。全球落髮治療用戶中,女性占比達54%。 [5] 對於存在遺傳落髮傾向體質的女性,一生中不同階段的激素變化,尤其是更年期前期與更年期的激素波動,會誘發或加重女性型落髮。」 雄激素性落髮帶來的影響遠不止於身體層面。落髮會給患者造成沉重的心理負擔,引發焦慮、自卑情緒,還會嚴重影響日常生活與社交活動 [6] ,這也進一步凸顯了早期診斷與有效治療的重要性。 綜合治療方案落地,落髮研究持續突破 REGAINE®落建作為全球歷經數十年深度研究與大量臨床驗證的落髮治療產品,始終未曾停下探索的腳步,不斷拓展毛髮再生科學的發展邊界。 今年五月,該品牌以鉑金贊助商身份亮相在韓國首爾舉辦的第十四屆世界毛髮研究大會。這一大會是毛髮科學領域極具權威性的學術盛會。 [7] 每一次進步都彌足珍貴 上述研究成果意義重大,對臨床醫學界與廣大消費群體均有著深遠影響。外用米諾地爾療效確切、安全性良好 [8] ,隨著業界對其在聯合治療中提升毛髮再生效果的作用機制有了更透徹的認知,REGAINE®落建也在持續創新,力求成為皮膚科醫生信賴的一線毛髮再生治療選擇。 關於 REGAINE® 落建品牌 REGAINE®落建是首個獲得美國食品藥品監督管理局(FDA)認證、適用於男性和女性毛髮再生的外用米諾地爾品牌。憑借38年的實證成果以及超過47,000人參與的臨床試驗,REGAINE®落建外用米諾地爾產品能夠有效延緩遺傳性落髮的進展。 * 該品牌在中國大陸(自貿區)及韓國市場以Rogaine®為名進行銷售。 [1] Ding Q, Xu YX, Sun WL, Liu JJ, Deng YY, Wu QF, Cao CY, Zhou LB, Lu Y, Fan WX. Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort. J Int Med Res. 2020 Mar;48(3):300060519897190. doi: 10.1177/0300060519897190. PMID: 32188323; PMCID: PMC7105740. [2] Liu LP, Wariboko MA, Hu X, Wang ZH, Wu Q, Li YM. Factors associated with early-onset androgenetic alopecia: A scoping review. PLoS One. 2024 Mar 7;19(3):e0299212. doi: 10.1371/journal.pone.0299212. PMID: 38451966; PMCID: PMC10919688. [3] Ho CH, Sood T, Zito PM. Androgenetic Alopecia. [Updated 2024 Jan 7]. In: StatPearls[Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430924/ [4] Nestor MS, Ablon G, Gade A, Han HW, Fischer DL. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. J Cosmet Dermatol. 2021 Nov 6;20(12):3759–3781. doi: 10.1111/jocd.14537. PMCID: PMC9298335 PMID: 34741573 https://pmc.ncbi.nlm.nih.gov/articles/PMC9298335/ [5] Hair Loss & Growth Treatments and Products Market. Market Growth Reports. Available from: Market Growth Reports [6] Li H, Li W, Zhang J, Liang Q, Zhao Y, Guo Z, Jiang B, Wang Z, Qu Q, An S, Miao Y. Risk factors for androgenetic alopecia: a systematic review and meta-analysis. BMC Public Health. 2026 Jan 28;26(1):1000. doi: 10.1186/s12889-026-26258-y. PMID: 41606541; PMCID: PMC13020014. [7] Kwangsun Choi, Basic therapy for hair loss treatment, the use of topical minoxidil, and case sharing, Proceedings at the World Congress of Hair Research, Seoul, South Korea [8] Hussein, RS, et.al, Applications and efficacy of minoxidil in dermatology. Skin Health Dis. 2024 Nov 24;4(6):e472. doi: 10.1002/ski2.472. PMCID: PMC11608877 PMID: 39624749. https://pmc.ncbi.nlm.nih.gov/articles/PMC11608877/#ski2472-bib-0012 嘉安家護股份有限公司 台北市中山區民生東路三段2號10樓 落建生髮慕絲5% 衛署藥輸字第025422號 落建女性專用生髮慕絲 衛部藥輸字第027051號 落建生髮液5% 衛署藥輸字第025697號 北市衛藥廣字第 115060234號
2026-07-02 02:00:00

Axtria Ignite 2026:450余位生命科学领域领导者齐聚,传递反常规信息----在规模化扩展AI之前,先夯实基础
450余位来自100多家顶尖生命科学组织的高管齐聚新泽西州普林斯顿,推动智能体AI走出概念验证阶段 创始人兼首席执行官Jaswinder "Jassi" Chadha向行业提出了一项反直觉的要求:在构建更多智能体之前,必须先夯实基础 Ignite领导力奖表彰了来自Bristol Myers Squibb、GSK和Biogen的转型领导者;Axtria Bedrock荣誉奖则认可了与Quest Diagnostics长达15年的合作伙伴关系 新泽西州伯克利海茨 2026年6月28日 /美通社/ -- 生命科学行业AI优先数据与分析解决方案及平台的全球领导者 Axtria Inc. 于6月10日至11日在Princeton Marriott at Forrestal(普林斯顿福里斯特尔万豪酒店)举办了 Axtria Ignite 2026 ,主题为“ 工业化智能:智能体企业 ”。 来自100多家顶尖生命科学、医疗科技及生物技术组织的450余位高管齐聚一堂,共同探讨2026年更为棘手的问题:企业在信任AI以机器速度运行之前,必须具备哪些条件。 这场仅限受邀者参加的活动,首日吸引了200多位与会者,参与AI、分析与商业卓越实践应用方面的产品工坊。 其中包括真实成功案例、智能体所带来的价值以及现场运行智能体的实操体验。 次日则安排了四场主会场讨论和16场专题讨论,涵盖四大主题:工业化数据与智能体基础架构、面向商业洞察的智能体AI、高绩效客户互动,以及从软件向智能体生态系统的转型。 Axtria Ignite现已进入第四届,成为生命科学领域高级商业与数据领导者日程中的固定活动。 基础即战略 在主题演讲中,Axtria创始人兼首席执行官Jaswinder "Jassi" Chadha指出,基础决定了制药行业AI能否规模化。 凭借在行业深耕三十年的经验,他指出了雄心与执行之间持续存在的差距:约73%的生物制药企业仍报告存在重大数据问题,多达89%的AI试点项目从未进入生产阶段,而对AI系统的信任度已从2019年的61%下滑至如今的53%,尽管行业正朝着预计超过10万个AI智能体的目标狂奔。 面对制药行业99.5%的准确率要求,Chadha提出了该基础必须具备的四项能力:AI就绪的数据供应链、保障智能体准确性的语义层、在最高风险环节提供确定性精度的软件防护栏,以及面向大规模数字员工的治理框架。 在他看来,智能体就是新入职的员工,必须通过验证和审计赢得信任,而非在入职第一天就获得信任。 Axtria创始人兼首席执行官Jaswinder "Jassi" Chadha表示: “在构建智能体之前,必须先夯实基础。 能够在智能体时代领先的企业,不是那些行动最快的,而是那些以信任为基础构建的企业。” 经CFO认证的商业价值 联合创始人兼首席技术官Navdeep "Navi" Chadha与Thermo Fisher Scientific和Quest Diagnostics的高层领导共同主持了一场主会场讨论。 讨论超越了未来潜力的层面,坦诚交流了行之有效与效果不佳的经验,涵盖可经CFO认证的价值报告、综合风险管理,以及在概念验证启动前明确定义退出标准的原则。 与会嘉宾反复提到的一个教训是:变革管理是核心工作,而非附属。 某高级数字领导者在主舞台专题讨论中表示:“变革管理与采纳落地,不能仅仅作为商业案例审批中30页演示文稿里的第45张幻灯片。” 与会者收获满满的对话 在各个专题分会中,交流达到了行业研究报告中所不具备的坦诚程度。 一家大型制药公司的高级领导描述了其团队的突破:明确传达AI是为了赋能营销人员而非取代他们。 据她所述,目前采纳率已超过90%。 某顶尖制药公司商业AI副总裁在主会场闭幕环节表示:“这不是一场AI革命, 而是一场人的革命。” Ignite领导力奖 Axtria颁发了年度Ignite领导力奖,表彰那些在各自组织内部推动艰难转型工作的领导者。 这些领导者因推动企业级AI转型、真正汇聚多方力量为AI基础建设做出实质性贡献,从而实现切实价值而获得认可。 2026年度获奖者包括: Bristol Myers Squibb商业化AI战略与分析副总裁Anvita Karara GSK医学事务IT副总裁Jeremy Pincus Biogen高级副总裁Bharti Rai Axtria Bedrock Honor Axtria Bedrock Honor授予了 Quest Diagnostics,以表彰长达15年的合作伙伴关系,以及近期实施的Axtria SalesIQTM 销售团队协同解决方案——该方案覆盖34种岗位类型和约1,300人的现场团队,是医疗保健行业最复杂的销售团队协同体系之一。 商业运营副总裁John Liffert,以及全国部署与协同总监Samantha Barnes-Weaver、商业卓越、薪酬与部署高级总监Marc Cangemi共同接受了这一荣誉。 Axtria创始人兼首席执行官Jassi Chadha表示:“在座了解Quest业务的人都知道,这可能是医疗行业最复杂的销售团队协同体系。 我们能够解决这一难题,而你们让我们变得更好, 也让我们的产品变得更好。 感谢大家在这一旅程中成为我们的合作伙伴。” 关于此次活动 Ignite 2026共邀请了 逾45位 嘉宾参与专题讨论与演讲,并举办了Axtria智能体产品(包括Axtria HIQ、Axtria SalesIQTM、Axtria MarketingIQTM和Axtria DataMAxTM)的实操工坊。 议程还包括高管激励薪酬圆桌会议,以及两晚的交流招待会。 关于Axtria Axtria帮助生命科学企业释放数据科学与软件的潜力,通过在合适的时间将合适的疗法匹配给合适的患者,从而改善患者治疗结果。 作为全球领先、屡获殊荣的云软件和数据分析供应商,Axtria提供经过验证的解决方案,帮助制药、医疗器械和诊断公司完成从数据到洞察再到行动的完整旅程。 作为联合国全球契约组织(UNGC)的参与者,Axtria致力于将战略和运营与人权、劳工、环境及反腐败等普遍原则保持一致。 如需了解更多信息,请访问 www.axtria.com 。
2026-06-27 19:07:00

havaianas 聯乘 Hypebeast Cup 巴西狂熱派對登陸 LA
隨著全球頂級足球賽事進入高潮,havaianas 聯同 Hypebeast 於 6 月 18 日在 Los Angeles 把一個場地打造成巴西綠洲,提前為 Brazil 上周五的賽事暖身。這個創立於 1962 年的人字拖品牌,突破一般看球框架,將國際級競賽的緊張張力,與地道巴西慶典的群體氛圍巧妙交織。活動期間捕捉到的一幕幕熱血瞬間,亦呈現出足球文化既是每個人極為私人的情感投射,同時亦是串連全球文化的共同語言。DJ Victoria Moura 以一連串巴西節奏點燃舞池,同時間吧檯送上 Caipirinhas、Batida Rosas 等招牌特調,營造宛如海灘派對的輕鬆氛圍。滿桌經典巴西小食與精緻小點亦與熱帶風情調飲相得益彰。為呼應現場一片 Brazil 主題造型海洋,會場以大量綠意裝置營造熱帶國度氣息,當中包括帶有海灘氛圍的產品陳列,以及由人字拖砌成的整面品牌牆。穿梭於場內多個互動空間,賓客最愛流連於 DIY flip-flop 客製站,在這裡可以為人字拖換上全新吊飾與裝飾細節。包括 Brenda La Latina 在內、負責拍攝活動回顧的多位 influencer 亦聚集於工作坊,為自己的涼鞋加上專屬點綴。無論是添上波希米亞風 macrame 流蘇,還是鑲有經典綠、黃、藍國旗色調的心形吊飾,每位到場者都親手創作出一份專屬今夜的獨一無二紀念品。把球場上的鬥志延伸到派對現場,來賓在會場中央即席展開數場節奏明快的桌上足球對決。為完整記錄這一夜的集體歡樂,活動特設拍照亭與一面由 havaianas 堆砌而成的巨型牆,成為拍攝大合照與展示全新客製人字拖的理想背景,尤其是來自 Top Nations 系列。這批於 havaianas 足球主題派對所拍下的照片,不僅見證品牌與這項國際運動之間深厚的文化連結,也印證它早已走出 Brazil,持續為全球造型美學注入靈感。 Click here to view full gallery at Hypebeast
2026-06-26 18:03:57

Que fais-tu?

0.028541088104248


Nouvelles
Nouvelles
Taïwan
Dernières nouvelles et titres
Taïwan
Nouvelles